New Findings Shed Light on Donor Cornea Storage Solutions

New Findings Shed Light on Donor Cornea Storage Solutions

Dr. Dan Polla, ARVO 2019

Previous studies in the field of corneal transplantation have determined the importance of endothelial cell density in the health of corneal tissue grafts in terms of graft success rate. According to new research presented this week at the 2019 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) in Vancouver, differences in the storage media solutions can have an effect on endothelial cell density.

Through the study, a retrospective analysis was conducted on a donor database from the Kansas City-based nonprofit Saving Sight to compare eye bank donor corneal endothelial cell density (ECD) after storage in Optisol GS and Life4°C solutions. The data analyzed included 24,581 donated eye bank corneas from 2011 through 2017 stored in Optisol GS or Life4°C solutions.

This project was led by Daniel Polla, MD, Ophthalmology Resident at Montefiore Medical Center and the Albert Einstein College of Medicine Department of Ophthalmology and Visual Sciences, in collaboration with Saving Sight.

“My project looks at the different storage media solutions that donor corneas were stored in from 2011 to 2017 at Saving Sight. The preliminary findings demonstrate a small difference in endothelial cell density after storage in Optisol GS or Life4°C, with a higher ECD after storage in Optisol GS. The differences found between donor corneas in each of the storage media groups may be due to factors that were not accounted for over time such as changes in processing protocols, equipment used to measure ECD, and variability in specular microscopy. While it is possible that Optisol GS better preserves the endothelium, one potential cause for the small difference in ECD between groups is variation in endothelial cell visualization during specular microscopy due to differences in solution color,” said Dr. Polla.

“This research is important to the field of ophthalmology and corneal transplantation because it may influence the way that corneas are stored and/or evaluated prior to transplantation, ultimately leading to better graft success rates and outcomes for patients.” Dr. Polla added.

Saving Sight Chief Business Development Officer Patrick Gore, RN, CEBT, Director of Business Development Lynn Forest-Smith, and Chief Operating Officer Tina Livesay were co-authors on the study. As an eye bank that facilitates eye donation for transplant and research, the Saving Sight team is proud to support this project and to work in collaboration with Montefiore and Drs. Polla, Rand and Chuck.

“We collect a large amount of data on all of our donor cases and corneas as a part of normal operations. This was a great opportunity to have these data parameters analyzed collectively for this study. As an eye bank, this allows us to help researchers advance the field of corneal transplantation to help honor the gift of sight through better recipient outcomes,” said Tina Livesay, Saving Sight Chief Operating Officer.

This study highlights the importance of collaboration between eye banks, medical centers and researchers in advancing the fields of corneal transplantation and ophthalmology.

 

Abstract: 

An analysis of donor corneas stored in Optisol GS and Life4°C solutions

Authors: Daniel J. Polla MD, Gabriel M. Rand MD, Patrick K. Gore RN CEBT, Lynn Forest-Smith CEBT, Tina Livesay CEBT, Roy S. Chuck MD PhD

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Research Findings - ARVO 2019

Dan Polla, MD, Ophthalmology resident at Montefiore Medical Center, details his latest research study with Saving Sight that he will present at ARVO 2019.

New Findings Presented on Factors Associated with DMEK Processing Damage

New Findings Presented on Factors Associated with DMEK Processing Damage

Dr. Gabriel Rand – ARVO 2019

According to new research presented this week at the 2019 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) in Vancouver, several potential risk factors, including donor diabetes mellitus, can lead to damage during Descemet Membrane Endothelial Keratoplasty processing.

There are limited studies identifying risk factors for damage when processing Descemet Membrane Endothelial Keratoplasty (DMEK), which has a high processing failure rate as compared to Descemet Stripping Automated Endothelial Keratoplasty (DSAEK). Through a study with lead researcher Gabriel Rand, MD, second year ophthalmology resident at Montefiore Medical Center and the Albert Einstein College of Medicine Department of Ophthalmology and Visual Sciences and Saving Sight, an analysis of potential risk factors was performed. Collaborative research partner, Saving Sight performs a high volume of DMEK processing.

Through the study, a retrospective analysis was completed with logistic regressions on all 385 DMEK tissues processed from 319 eligible donors at Saving Sight from July 2014 to June 2017. The study concluded that eye bank DMEK processing has significant rates of damage and risk factors for processing failure including donor diabetes mellitus, individual technician ability and the technician learning curve.

“Myself, Dr. Chuck and a bunch of us here at Montefiore have been working with Saving Sight to prepare an abstract for ARVO this year,” said Dr. Rand. “The topic of the abstract is the effect that donor diabetes status has on the corneal transplant quality. This is a really important subject because diabetes is a disease that is increasing in prevalence every year and it’s a multisystem disease – it affects every single part of the body, the cornea notwithstanding. There’s really not a tremendous amount of literature on what the potential influences that donor diabetes status has on these cornea transplant tissues. So what our contribution is, is to add to the fund of knowledge and to really examine does a donor diabetes status affect endothelial cell health, does it affect preparation failure rates, things like this, so it’s been a really exciting research project for us.”

Saving Sight Chief Business Development Officer Patrick Gore, RN, CEBT, Director of Business Development Lynn Forest-Smith, and Chief Operating Officer Tina Livesay were co-authors on the study. As an eye bank that facilitates eye donation for transplant and research, the Saving Sight team is proud to support this project and to work in collaboration with Montefiore and Drs. Rand and Chuck.

“It is a privilege for me to work with such a devoted team at Montefiore who want to advance the science of ophthalmology,” said Lynn Forest-Smith, Director of Business Development at Saving Sight. “I have a real passion for the work we do at Saving Sight and teaming up with these folks allows us to take our findings back to the eye banks, apply what we learn to improve our services and ultimately, help more people see.”

This collaborative study helps advance the fields of corneal transplantation and ophthalmology between eye banks, medical centers and researchers and helps identify factors that contribute to better grafts and better outcomes for patients.

Abstract:

Factors associated with eye bank descemet membrane endothelial keratoplasty processing damage

Authors: Gabriel M. Rand MD, Patrick K. Gore RN CEBT, Lynn Forest-Smith CEBT, Tina Livesay CEBT, Roy S. Chuck MD PhD

 

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Research Findings - ARVO 2019

Gabriel Rand, MD, second-year Ophthalmology resident at Montefiore Medical Center, gives an overview of his recent research collaboration with Saving Sight for ARVO 2019

The Value of Research Collaborations – Eye Banks and Researchers

The Value of Research Collaborations – Eye Banks and Researchers

Saving Sight is honored to be co-authors with Montefiore Medical Center and Albert Einstein College of Medicine on two research presentations at the 2019 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO). Collaborating with ophthalmology residents and leading researchers and surgeons helps drive vision-research forward. These projects highlight how much is gained in advancing research in corneal transplantation through collaborations with eye banks, medical centers and researchers. Working together allows us to honor the gift of sight and advance the treatment of corneal disease.

Dr. Roy Chuck, Dr. Gabriel Rand, and Dr. Dan Polla

“Some of our major presentations at the ARVO meeting this year are based on our partnership with the Saving Sight eye bank, who have been just a pleasure to work with,” said Dr. Roy Chuck, Chairman of Ophthalmology and Visual Sciences at the Albert Einstein College of Medicine and the Montefiore Medical Center. “They are very forward looking in the world of eye banking in that they have gone ahead and developed a very organized and large electronic database. In this age of research in our field of ophthalmology, and really in medicine in general, it’s all about big data.”

“We think of ourselves as forward-thinking and part of the forward-thinking is figuring out appropriate ways to work with our partners outside of the academic community, which includes eye banks and industry. What you’ll see in our research are very good collaborations that are appropriate and the right way to look forward as we develop science in this new era,” added Dr. Chuck.

Dr. Chuck is proud to work with his residents, Dr. Gabriel Rand and Dr. Dan Polla in their research endeavors. Drs. Polla and Rand are lead authors on the two research presentations that will be presented at ARVO 2019. Read why they value research collaborations:

 

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“The collaboration between Saving Sight and Montefiore is very important and beneficial because we all ultimately have the same goal, which is to restore and improve sight in those in need. By collaborating, we are able to help each other be better in what we respectively do, ultimately leading to better outcomes on both fronts,” said Dan Polla, MD, Ophthalmology Resident at Montefiore Medical Center.

“Cornea and corneal transplants are such exciting field and I feel really lucky and grateful to be a part of it and to be doing research that makes an impact.”

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“Working with Saving Sight has been an amazing opportunity for me. I’ve been working on research projects with them that involve looking at their large databases and trying to find factors that influence the quality of the corneal grafts that come out of the eye bank,” said Dr. Gabriel Rand, Second Year Ophthalmology Resident at Montefiore Medical Center. “This has been such an incredible opportunity because, not only as a resident do I get to experience taking care of patients in the clinic and operating room, but I can also participate in the science of advancing care for patients and helping to identify factors that contribute to better grafts and better patient outcomes.”     

About Saving Sight

Saving Sight is a nonprofit eye bank with a mission to change lives by saving sight. Founded in 1960, Saving Sight has grown to become one of the nation’s leading eye banks and is focused on providing innovative solutions to its clinical and research partners. Saving Sight welcomes customized research collaborations that meet your research tissue needs and strives to advance the field of corneal transplantation through dynamic collaborations with medical centers and researchers. Headquartered in Kansas City, Mo., Saving Sight facilitates eye donation in Missouri, Kansas, and Illinois, serving transplantation and research specialists locally and around the world. 

 

Happy Holidays from Saving Sight!

Happy Holidays from Saving Sight!

Happy Holidays from Saving Sight!

Cynthia captured the crisp, winter scene pictured as our 2018 featured holiday artist.

Happy Holidays!

Thanks to our staff, partners, volunteers and supporters of our work in eye donation, more corneal recipients like Cynthia are able to enjoy the twinkling holiday lights and watch the first snowfall of the season. And more donor families are able to find comfort in their loved one’s legacy living on through the gift of sight in 2018.

We wish you a bright holiday season and look forward to our continued work in the new year. Happy Holidays, from all of us at Saving Sight!

 

 

About the Artist

Thanks to the generosity of three eye donors, Cynthia was able to correct her vision through the gift of sight. “Prior to the loss of my sight at the age of 20, I was a photographer, so you can see how important my eyes were to me,” she says. Cynthia has Keratoconus and started losing her sight due to the thinning of her cornea that caused blurred vision. “My hope of recovering my eyesight came in the form of eye donors and skilled surgeons and physicians. Words cannot express what kind of hope I was given through the blessings of people I do not know.”

November is Eye Donation Month

November is Eye Donation Month

November is Eye Donation Month! Eye Bank Association of America (EBAA) uses the month as an opportunity to educate the public about the importance of registering to be a donor, about cornea donation and transplantation, and to acknowledge the work of their partner eye banks. As a member eye bank, Saving Sight will be taking part in celebrating Eye Donation Month and the theme of The Power of You. The campaign demonstrates the “power” that individuals have in building hope, restoring sight and changing lives, including healthcare professionals and partners, researchers, eye bank staff, corneal surgeons, and recipients and donor families.

We will be sharing several cornea recipient and donor family stories in November. Be sure to follow Saving Sight on Facebook and on our website during November for #EyeDonationMonth. Thank you for helping us change lives by saving sight! 

 

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November is Eye Donation Month! Eye Bank Association of America (EBAA) uses the month as an opportunity to educate the public about the importance of registering to be a donor, about cornea donation and transplantation, and to acknowledge the work of their partner eye...

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As an eye bank, Saving Sight is an integral part in the journey of the cornea, recovering donor tissue to honor the gift of sight, processing and evaluating the tissue in our laboratory, and then distributing the tissue to corneal surgeons for transplant. During the 2017-2018 fiscal year, Saving Sight provided corneal tissue to 2,957 transplant recipients locally and throughout the world thanks to the selfless gift of sight from 2,480 eye donors and their families.

 

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Vicki was a loving and caring person who always wished to help others. She loved the outdoors, decorating and design, and reading in her Bible. Most of all, she loved her family and was a proud mother of 3 children, grandmother to 13 and great-grandmother to 9.For the past ten years, Vicki had been in ill health and, while under hospice care, she made her wishes known she would like to donate her corneas. “As Vicki’s sister, I lost my sight in my right eye after cataract surgery so we hope that Vicki’s gift will help someone else see,” says Cricket, whose given name is Barbara but her little sister Vicki always lovingly called her Cricket. Vicki and Cricket had discussed organ donation, but knew with her health she’d likely be an eye and tissue donor. (Click here to read her full story)

 

Regaining Sight After 23 Years – Cornea Transplant Recipient

For 23 years, Angela was 100 percent blind in her right eye. Thanks to the generous gift of sight from an eye donor and the work of her surgeons, she has regained her sight! When Angela went in for what was a routine eye exam to get new contacts in 2017, her eye doctor expressed concerns about her right eye (which she had been blind in for as long as she can remember) and thought she might have Keratoconus. Her doctor referred her to see an ophthalmologist at MU Health Care. “The following week, when I met my would-be surgeons, they confirmed I had severe Keratoconus, explained what it was, what my options were, and what it would mean if I opted not to do the surgery,” says Angela. “After going over all the pros and cons with my family and the risks (which were incredibly minimal due to my current condition), I scheduled my surgery the following month.” The Power of Donation “Words could never adequately describe how thankful I am,” says Angela of her eye donor. “It did so much for me, much more than what any of my doctors or I believed could happen. It really can change someone’s life in an  incredibly positive way.” Angela has been a registered organ, eye and tissue donor since she was 14-years-old and it’s a cause that is near to her heart. “Now, being on the other side of it, it has given me a deeper affection for donation.” (Click here to read her full story)