Continued Collaboration Leads to Further Study of the Development of Myopia

Continued Collaboration Leads to Further Study of the Development of Myopia

Continued Collaboration Leads to Further Study of the Development of Myopia

Lynn Forest-Smith, Director of Business Development at Saving Sight, with Dr. Jody Summers at ARVO 2019 in Vancouver.

Kansas City, Mo., August 21, 2019 – Jody Summers, PhD, professor of cell biology at the University of Oklahoma Health Sciences Center, studies the extracellular matrix of the sclera and changes associated with myopia development. Myopia is largely regulated by the visual environment. Through her studies, she hopes to understand why myopia interacts the way it does so intervention is possible.

“Nearly 50 percent of the world’s population will be myopic by 2050,” says Dr. Summers. “In some countries, such as those in East Asia, myopia is the leading cause of blindness. It can be completely preventable with how the eye responds to the visual environment if we can learn why.”

As a postdoctoral fellow in ophthalmology, Dr. Summers identified that there was little research with regard to the sclera. “Through research, I discovered that the sclera is not just a static container in the eye. The sclera is actually very active and can alter its compositions to control the refractive state or length of the eye. What happens in myopia is the sclera begins to elongate. Because sclera is a very responsive tissue, we are trying to understand how sclera remodeling happens so we can work to regulate it – which has taken us to this study.”

Saving Sight was honored to be a co-author on a research project at the 2017 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) with Dr. Summers, titled Isolation and Transcriptome Analyses of Choroidal Retinaldehyde Dehydrogenase-2 (RALDH2) Expressing Cells.

At ARVO 2017, Dr. Summers successfully isolated cells in the choroid (the vascular layer of the eye, located between the sclera and the retina) of both chick and human eyes which have been found to produce the enzyme retinaldehyde dehydrogenase 2 (RALDH2).

“The ARVO abstract was preliminary research to see if we could isolate those cells,” says Dr. Summers. “We first had a pilot study where Saving Sight provided us with two, reduced fee whole globes. This showed we could isolate the retinoic acid in the choroid.”

In summer 2019, Dr. Summers received National Eye Institute at NIH funding to further study the isolated cells through transcriptome analyses. Part of that grant contributes to the fees associated with receiving 10 whole globes or poles (which is the whole eye minus the cornea) from Saving Sight. “This next step is to do it again and do the transcriptome analyses to identify the cells in the choroid that make the retinoic acid.”

Dr. Summers adds that retinoic acid is a powerful chemical and they are interested in identifying the cells that produce it. “If we identify these cell types we can, perhaps, use that information to develop strategy to control the synthesis of retinoic acid,” she says.

Since the human genome has been sequenced, Dr. Summers will be able to sequence the cells from the choroid and compare with the human genome sequence to gather more information as to which cell type is responsible for retinoic acid synthesis.

Collaboration between Researchers and Eye Banks

“I value working with Saving Sight because it was very easy to get the collaboration set up,” says Dr. Summers. “I love that they are interested in research and feel like it’s a two-way relationship. I’m really glad they are available and willing to introduce a new technique or procedure that is compatible for research.”

Dr. Summers adds that one of most valuable connections in eye banks and researchers working together is the ability for Saving Sight to provide human eye tissue for research. “NIH funded research hopes to help humans through the betterment of health. Being able to provide tissue like Saving Sight does under the conditions needed is of value because not many eye banks do that.”

About Saving Sight

Saving Sight is a nonprofit eye bank with a mission to change lives by saving sight. Founded in 1960, Saving Sight has grown to become one of the nation’s leading eye banks and is focused on providing innovative solutions to its clinical and research partners. Saving Sight welcomes customized research collaborations that meet your research tissue needs and strives to advance the field of corneal transplantation through dynamic collaborations with medical centers and researchers. Headquartered in Kansas City, Mo., Saving Sight facilitates eye donation in Missouri, Kansas, and Illinois, serving transplantation and research specialists locally and around the world.

Click here to learn more about Saving Sight’s customized research collaborations.

Support Saving Sight and Help Honor Eye Donors

Support Saving Sight and Help Honor Eye Donors

Last year, 2,559 heroes gave the gift of sight through eye donation with Saving Sight. Help us honor these donors on this year’s Donate Life Rose Parade Float.

Saving Sight has launched a t-shirt fundraiser with Bonfire, a shirt platform that works with nonprofit organizations. We will be selling three designs, available in July, August and September respectively. The proceeds from the sale of these shirts will be used to purchase roses in memory of our donors.

Each year, Donate Life’s Rose Parade float features riders representing transplant recipients; living donor walkers; and dozens of memorial “floragraph” portraits of deceased organ, eye and tissue donors. The deck of the float is also covered with thousands of dedicated roses with vials carrying personal messages of love, hope and remembrance.

To purchase a shirt, visit www.bonfire.com/store/saving-sight/. Shirts available for purchase July 1-21st, August 1-21st, and Sept 1-21st. At the conclusion of each campaign, the shirts will be shipped directly to the purchaser the last week of each month.

 

Saving Sight Thanks Outgoing Board of Directors and Introduces the 2019-2020 Board of Directors

Saving Sight is pleased to welcome three new people to its Board of Directors for the 2019-2020 fiscal year (July 1 – June 30). Welcome Council Chair Lion Walt Hamer, Vice-Council Chair Lion George Winkeler, Jr., and Lion Al Dohmen. Immediate Past Vice-Council Chair Lion Pat Scott will continue on the board representing Lions district M-5.

CC Lion Walt Hamer

VCC Lion George Winkeler, Jr.

M-6 Lion Al Dohmen

Board members are key to the organization’s success. They actively participate in long-range planning and monitor the organization’s financial health and overall performance. As highly visible members of their communities, the board members also enhance Saving Sight’s public standing by sharing the mission, accomplishments, and goals with Lions clubs, the general public, and other partner organizations. As Lion board members, these individuals also keep their districts informed about Saving Sight.

“We are able to change more lives by saving sight due to our board members engagement, leadership, support and oversight,” said Tony Bavuso, chief executive officer.

In addition to welcoming new members to the board, Saving Sight also expressed gratitude to three individuals who retired from the board of directors on June 1, 2019. “We were honored to have Lion Allen Lohsandt, PCC Ron Campbell, and PDG Stuart Payne serve on our board,” Bavuso said. “On behalf of the staff and the recipients of our programs, I thank them for their valuable service and wish them all the best.” PCC Ron Campbell was elected to a three year term as an honorary board of director member.

Board President Pat Martchink presenting Lion Allen Lohsandt with a plaque in recognition of his service.
Board President Pat Martchink presenting Lion Allen Lohsandt with a plaque in recognition of his service.
Board President Pat Martchink presenting PCC Ron Campbell with a plaque in recognition of his service.
Board President Pat Martchink presenting PDG Stuart Payne with a plaque in recognition of his service.

At the June Board of Directors meeting, the board elected its 2019-2020 leadership team.
These board members were elected to leadership roles for the new fiscal year:

President: Lion Pat Martchink, MD-26 M2
Vice President: IPCC Larry Boettcher, MD-26 M4
Treasurer: Lion Mike Oldelehr, MD-26 M7
Secretary: Lion Cassidy Obermark, OD, MD-26 M1

Congratulations to the leadership team. To see the full listing of Saving Sight’s board of directors, visit our Leadership Page.

Retired Judge Gary Schmidt Shares His Story as a Corneal Transplant Recipient

Retired Judge Gary Schmidt Shares His Story as a Corneal Transplant Recipient

April was National Donate Life month and Saving Sight took part in numerous celebrations in Missouri, Kansas and Illinois to help spread awareness about the impact of organ, eye and tissue donation.

On April 9th, Saving Sight was honored to take part in Donor Family Recognition Day at the Missouri State Capitol. During the event, donor families were honored by the Governor and were also introduced on the House floor. We also had the great privilege of having one of our cornea recipients, retired Judge Gary Schmidt, speak at the event to share about the impact corneal transplantation has had on his life.

Schmidt finds it very meaningful to speak at events like this. “It gives me an opportunity to express my gratitude to the families of donors of all types. Donors have done so much to improve the lives, perhaps save the lives of others. It is a privilege to say ‘Thank you!’ I’m not able to find the words to adequately express the debt of gratitude we owe them.”

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Watch Retired Judge Gary Schmidt Share His Story at Donor Family Recognition Day at the Missouri State Capitol

“Donors have done so much to improve the lives, perhaps save the lives of others. It is a privilege to say ‘Thank you!’ I’m not able to find the words to adequately express the debt of gratitude we owe them.”

Gary Schmidt, Cornea Recipient

After the event, Judge Schmidt followed up with Saving Sight to discuss his experience in further detail:

Saving Sight: Judge Schmidt, can you tell us about your experience with corneal transplantation?

Schmidt: What I remember most is the fear. When my corneas both went bad at the same time, I was almost completely blind. It happened in a few short days, and I wasn’t prepared for the possibility I might be sightless for the rest of my life.

Saving Sight: What caused you to require a transplant?

Schmidt: My corneas both failed from a combination of diabetes, age and bad genes.

Saving Sight: What was your transplant experience like?

Schmidt: Unfortunately, it didn’t go smoothly. Dr. Leutkemeyer elected to do my left eye first and, after being placed, the graft moved out of position. It took several trips to surgery before the graft took and held. The right eye went much more smoothly, and I was seeing quite well within a few days.

Saving Sight: Did you have a connection to organ, eye and tissue donation prior to your transplant?

Schmidt: When I was first out of law school, an old high school classmate took on a project of signing up many bone marrow transplant donors. I was one of her targets. The idea didn’t take much selling; registering as a bone marrow donor might save a life. So I registered, and got an immediate preliminary match. Unfortunately further testing showed we were not compatible. Ultimately, several of my high school classmates did indeed donate bone marrow.

Saving Sight: What’s something you learned about the donation process through your experience?

Schmidt: I am constantly amazed at the things that may be donated, both while the donor is living and postmortem.

Saving Sight: What is something you’d like others to know about the process?

Schmidt: I would hope that everyone is aware of how much donation can change the world for a person, for a family. In my case, my donor gave me the gift of sight. Some donors are able to save lives.

Saving Sight: What are some things you enjoy to do and are able to do now that your sight is restored?

Schmidt: If I couldn’t see, I’d be a huge burden to my family. The gift of sight gives me independence, and keeps me from being a burden to them. I can now do all the things I enjoy, including going to high school football games and reading. It was always my dream to spend retirement reading all the things I never had time to read when I was working full time.

Saving Sight: What caused you to write to your donor family through our Correspondence Program?

Schmidt: Considering what my donor did for me, how could I not try and express my gratitude for their relative that did so much for me? In my case, I hope they are proud of the very good things their donor was able to accomplish. They should be very proud of him.

Saving Sight: Why is speaking at events like Donor Day at the Capitol meaningful to you as a cornea recipient?

Schmidt: It gives me an opportunity to express my gratitude to families of donors of all types. Donors have done so much to improve lives, perhaps save the lives of others. It is a privilege to say “Thank you!” I’m not able to find the words to adequately express the debt of gratitude we owe them.

Saving Sight: Is there anything else about your experience you would like to mention?

Schmidt: I think it must be incredibly satisfying to work with an agency (Saving Sight) that does so much good. Before my eyes failed I was vaguely aware that someone must be tending to such things. Now I can put smiling faces to some of the people who are doing such incredible work.

 

New Findings Shed Light on Donor Cornea Storage Solutions

New Findings Shed Light on Donor Cornea Storage Solutions

Dr. Dan Polla, ARVO 2019

Previous studies in the field of corneal transplantation have determined the importance of endothelial cell density in the health of corneal tissue grafts in terms of graft success rate. According to new research presented this week at the 2019 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) in Vancouver, differences in the storage media solutions can have an effect on endothelial cell density.

Through the study, a retrospective analysis was conducted on a donor database from the Kansas City-based nonprofit Saving Sight to compare eye bank donor corneal endothelial cell density (ECD) after storage in Optisol GS and Life4°C solutions. The data analyzed included 24,581 donated eye bank corneas from 2011 through 2017 stored in Optisol GS or Life4°C solutions.

This project was led by Daniel Polla, MD, Ophthalmology Resident at Montefiore Medical Center and the Albert Einstein College of Medicine Department of Ophthalmology and Visual Sciences, in collaboration with Saving Sight.

“My project looks at the different storage media solutions that donor corneas were stored in from 2011 to 2017 at Saving Sight. The preliminary findings demonstrate a small difference in endothelial cell density after storage in Optisol GS or Life4°C, with a higher ECD after storage in Optisol GS. The differences found between donor corneas in each of the storage media groups may be due to factors that were not accounted for over time such as changes in processing protocols, equipment used to measure ECD, and variability in specular microscopy. While it is possible that Optisol GS better preserves the endothelium, one potential cause for the small difference in ECD between groups is variation in endothelial cell visualization during specular microscopy due to differences in solution color,” said Dr. Polla.

“This research is important to the field of ophthalmology and corneal transplantation because it may influence the way that corneas are stored and/or evaluated prior to transplantation, ultimately leading to better graft success rates and outcomes for patients.” Dr. Polla added.

Saving Sight Chief Business Development Officer Patrick Gore, RN, CEBT, Director of Business Development Lynn Forest-Smith, and Chief Operating Officer Tina Livesay were co-authors on the study. As an eye bank that facilitates eye donation for transplant and research, the Saving Sight team is proud to support this project and to work in collaboration with Montefiore and Drs. Polla, Rand and Chuck.

“We collect a large amount of data on all of our donor cases and corneas as a part of normal operations. This was a great opportunity to have these data parameters analyzed collectively for this study. As an eye bank, this allows us to help researchers advance the field of corneal transplantation to help honor the gift of sight through better recipient outcomes,” said Tina Livesay, Saving Sight Chief Operating Officer.

This study highlights the importance of collaboration between eye banks, medical centers and researchers in advancing the fields of corneal transplantation and ophthalmology.

 

Abstract: 

An analysis of donor corneas stored in Optisol GS and Life4°C solutions

Authors: Daniel J. Polla MD, Gabriel M. Rand MD, Patrick K. Gore RN CEBT, Lynn Forest-Smith CEBT, Tina Livesay CEBT, Roy S. Chuck MD PhD

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Research Findings - ARVO 2019

Dan Polla, MD, Ophthalmology resident at Montefiore Medical Center, details his latest research study with Saving Sight that he will present at ARVO 2019.